Fragmentosis is a surreal game featuring roguelite deckbuilding and first-person combat, with influences from games of the 1990s and 2000s. In its Balatro-inspired Lab mode, players combine fragments into inventions, build scoring combinations, and upgrade their decks while raising Fragmentosis Fever. Combat modes include wave-based Fever Run, minecart-based Rail Shooter, and Instruments Only, where inventions replace conventional weapons.